Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Drosophila Melanogaster Sex Linked Recessive Lethal Test of Cyclohexanone with Cover Letter dated 101586 (Final Report).
CORP Author Wisconsin Univ., Madison.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8666139
Stock Number OTS0511205
Additional Subjects Toxicology ; Health effects ; Cyclohexanone ; Genotoxicity ; Gene Mutations ; Insects ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 108-94-1
Library Call Number Additional Info Location Last
NTIS  OTS0511205 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 11p
The ability of cyclohexanone to induce sex-linked recessive lethal mutations in the post-meiotic germ cells was evaluated in Drosophila males (wild-type stock, Canton-S). Based on preliminary toxicity determinations, Drosophila (689, 1343, 1008 and 892/treated groups and 559, 1203, 1213, and 892/control groups) were treated with cyclohexanone via inhalation at vapor concentrations of 0 (control group) or 36% for 4 hours. Surviving flies were mated with 3 sets of 3 virgin 'Basc' females for 72 hours each. Percent mortalities during exposure and the following 21 hours averaged 32% in the treated groups versus 0% in the controls. Male sterility was slightly increased in treated flies. There was no indication of any mutagenic effect in any germ cell stage in treated male Drosophila (percent lethals for treated and control groups were 0.071% and 0.070%, respectively).