| Main Title |
Antagonism of Chlorobenzene-Induced Hepatotoxicity by Lindane. |
| Author |
Chadwick, R. W. ;
Scotti, T. M. ;
Copeland, M. F. ;
Mole, M. L. ;
Froehlich, R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA-600/J-84-032; |
| Stock Number |
PB84-206119 |
| Additional Subjects |
Chlorine organic compounds ;
Dosage ;
Metabolism ;
Reprints ;
Lindane ;
Cyclohexane/hexachloro ;
Hepatotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-206119 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
In a 2x2 factorial designed experiment involving chlorobenzene and gamma-hexachlorocyclohexane (lindane), the hepatotoxicity induced by a challenge dose of chlorobenzene was altered by the pretreatments due to selective changes in various metabolic pathways. These changes resulted in either (1) a marginally significant decrease in hepatotoxicity (chlorobenzene-pretreatment); (2) significant reduction in both the incidence and severity of the lesions (lindane-pretreatment); or (3) absence of centrilobular hepatocellular necrosis in all but 1 of 12 rats where a minimal degree of necrosis was present (chlorobenzene + lindane-pretreatment). |
