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RECORD NUMBER: 75 OF 108

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Main Title

Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide1.

Author

Gold, Avram ; Nesnow, Stephen ; Moore, Martha ; Garland, Helen ; Curtis, Gaynelle ;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC.

Year Published

1980

Report Number

EPA-600/J-80-304;

Stock Number

PB81-222234

Additional Subjects

Toxicology ; Cells(Biology) ; Morphology ; Mammals ; Cultures(Biology) ; Mutations ; Nitrogen organic compounds ; Reprints ; Cyclopentapyrene ; Mutagenesis ; Toxic substances ; Cell cultures ; Metabolites ; Cyclopentapyrene oxide

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB81-222234	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

Cyclopenta(cd)Pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to a be direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.

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