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RECORD NUMBER: 21 OF 109

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Main Title

Cytotoxicity of Halogenated Alkanes in Primary Cultures of Rat Hepatocytes from Normal, Partial Hepatectomized, and Preneoplastic/Neoplastic Liver.

Author

Chang, L. W. ; Pereira, M. A. ; Klaunig, J. E. ;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo.

Year Published

1985

Report Number

EPA/600/J-85/219;

Stock Number

PB86-121506

Additional Subjects

Halogen organic compounds ; Toxicity ; Environmental surveys ; Bioassay ; Biochemistry ; Laboratory animals ; Risk ; Metabolism ; Rats ; Exposure ; Hazardous materials ; Cultures(Biology) ; Chloroform ; Liver neoplasms ; Reprints ; Toxic substances ; Environmental health ; Carcinogenesis ; Ethane/dibromo ; Ethane/dichloro ; Ethane/trichloro

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB86-121506	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

12p

Abstract

Six halogenated hydrocarbons: chloroform, 1,2-dibromoethane (1,2-DBE), 1,1-dichloroethane (1,1-DCE), 1,2-dichloroethane (1,2DCE), 1,1,1-trichloroethane (1,1,1-TCE) and 1,1,2-trichloroethane (1,1,2-TCE) were evaluated for their cytotoxicity in primary cultures of rat hepatocytes isolated from normal, partial hepatectomized and from preneoplastic/neoplastic rat liver. None of the six halogenated alkanes exhibited any difference in their cytotoxicity toward hepatocytes isolated from normal liver or from liver containing preneoplastic/neoplastic lesions induced by either procedure.

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