Record Display for the EPA National Library Catalog


Main Title Vertebrate toxicology of the solubilized proteins of Bacillus thuingiensis subsp. 'israelensis' {microform} /
Author Roe, R. Michael. ; Kallapur, V. L. ; Dauterman, W. C. ; Edens, F. W. ; Mayes., M. E.
Other Authors
Author Title of a Work
Kallapur, V. L.
Dauterman, W. C.
Edens, F. W.
Mayes, M. E.
Held, G. A.
Kawanishi, C. Y.
Alford, A. R.
Clifford, C. W.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;Maine Univ. at Orono. Dept. of Entomology. ;Northeastern Oklahoma State Univ., Tahlequah.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory, Health Effects Research Laboratory,
Year Published 1992
Report Number EPA/600/A-92/028
Stock Number PB92-150507
Subjects Pesticides--Toxicology ; Pesticides--Environmental aspects ; Pesticides--Technological innovations ; Pesticides--toxicity ; Environmental Pollution ; Technology
Additional Subjects Bacillus thuringiensis ; Biological pest control ; Bacterial proteins ; Toxicity ; Vertebrates ; Mammals ; Environmental exposure pathways ; Nervous system ; Muscles ; Hemolysis ; Culicidae ; Heart rate ; Mice ; Coturnix ; Body temperature ; Bti parasporal crystal
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB92-150507 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20 p. : ill. ; 23 cm.
The review summarizes the studies done with the mammalian toxic Bacillus thuringiensis subsp, israelensis (Bti) 28 kDa cytA protein. The data is relevant to hazard identification studies with bacterial pesticides. The data shows the cytA produces lethal physiological changes in diverse mammalian species when administered intraperitoneally and a dose-dependent localized necrosis by the subcutaneous route. Challenge by other routes have no effects. The cytA protein is a minor component of the insecticidal activity of the Bti parasporal crystal. Insertion of the cytA gene by genetic engineering methods into microbial species that have the potential to invade traumatized tissues or organs could result in detrimental human health effects.
Includes bibliographical references.