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Main Title Mutagenicity Evaluation of C-56 (crotonaldehyde) in the Ames Salmonella/microsome Plate Test (final Report) with Cover Letter Dated 03/11/1987.
CORP Author Litton Bionetics, Inc., Bethesda, MD.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1987
Report Number 86870000237
Stock Number OTS0513187
Additional Subjects Toxicology ; Health effects ; Crotonaldehyde (2-butenal) (4170-30-3) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 4170-30-3
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0513187 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Abstract
The mutagenicity of crotonaldehyde was evaluated in Salmonella tester strains TA1535, TA1537, TA1538, TA98 and TA100, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary bacterial toxicity determinations, crotonaldehyde was tested for mutagenicity at concentrations of 0.005, 0.01, 0.10, 1.0, 5.0 and 10.0 ul/plate using the agar incorporation method. Crotonaldehyde did not produce a positive response in any bacterial tester strain, either with or without metabolic activation. The investigators reported crotonaldehyde was toxic to all bacterial strains at concentrations of 1, 5 and 10 ul/plate.