| Main Title |
Glucocorticoids Regulate the Concentration of Glial Fibrillary Acidic Protein Throughout the Brain. |
| Author |
O'Callaghan, J. P. ;
Brinton, R. E. ;
McEwen., B. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Rockefeller Univ., New York. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/404; |
| Stock Number |
PB90-245911 |
| Additional Subjects |
Corticosterone ;
In vivo analysis ;
Adrenalectomy ;
Reprints ;
Glucocorticoids ;
Brain chemistry ;
Glial fibrillary acidic protein ;
Pharmacology
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-245911 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The role of glucocorticoids in the in vivo regulation of glial fibrillary acidic protein was examined. Corticosterone administration to adult rats resulted in decreased levels of GFAP throughout the brain whereas adrenalectomy caused levels of GFAP to increase. Corticosterone administration to adrenalectomized rats lowered GFAP levels to values below those of sham controls. Thus, the expression of GFAP throughout the brain appears to be physiologically regulated by adrenal glucocorticoids. (Copyright (c) 1989 Elsevier Science Publishers B. V. (Biomedical Division)). |
