Record Display for the EPA National Library Catalog


Main Title Effect of 2 percent venous carboxyhemoglobin on exercise-induced angina pectoris /
Author Aronow, Wilbert S.
CORP Author Veterans Administration Medical Center, Long Beach, CA.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1981
Report Number EPA/600/1-81/012
Stock Number PB81-152480
Subjects Angina Pectoris ; Carbon Monoxide--adverse effects ; Hemoglobins--analysis
Additional Subjects Angina pectoris ; Carbon monoxide ; Toxicology ; Concentration(Composition) ; Exposure ; Coronary artery disease ; Patients ; Exercise(Physiology) ; Epidemiology ; Risk ; Air quality ; Carboxyhemoglobin ; Angina pectoris ; Toxic substances ; Environmental health ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB81-152480 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 49 pages ; 28 cm
In a double-blind, randomized, crossover study, 14 patients with angina pectoris who breathed carbon monoxide 50 ppm for 1 hour to raise the mean venous carboxyhemoglobin from 1.09 to 2.02% had a reduction in mean exercise time until angina pectoris from 321.7 to 289.2 seconds, P<0.001. After breathing compressed, purified air to reduce the mean venous carboxyhemoglobin from 1.07 to 1.00% , there was an insignificant increase in mean exercise time until angina pectoris from 324.5 to 330.3 seconds. In comparison with the control period or after breathing compressed purified air, a 2.02% venous carboxyhemoglobin level caused a reduction in exercise time until angina pectoris, P<0.001, no significant change in resting sytolic blood pressure times heart rate, a reduction in systol blood pressure times heart rate at angina pectoris, P<0.001, and no significant change in exercise-induced ischemis S-T segment depression. These data indicate that a 2% venous carboxyhemoglobin level aggravates angina pectoris.
"January 1981." "EPA 600/1-81-012." Final report. Sponsored by the Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency. Includes bibliographical references (leaves 31-33). Microfiche.