Record Display for the EPA National Library Catalog


Main Title Production of Arrhythmias by Elevated Carboxyhemoglobin in Patients with Coronary Artery Disease.
Author Sheps, D. S. ; Herbst, M. C. ; Hinderliter, A. L. ; Adams, K. F. ; Ekelund, L. G. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/430;
Stock Number PB91-171850
Additional Subjects Arrhythmia ; Carboxyhemoglobin ; Carbon monoxide ; Coronary artery disease ; Double-blind method ; Tables(Data) ; Exercise ; Stroke volume ; Adrenergic beta receptor blockaders ; Calcium channel blockers ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-171850 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Sudden death frequently occurs from coronary artery disease. It almost always results from cardiac arrhythmias and is often the first and only clinically recognizable manifestation of the disease process (1). Because of the relations among cardiac arrhythmias, sudden death, and coronary artery disease, as well as the high prevalence of coronary artery disease in the United States today, it is important to answer the question of whether or not exposure to carbon monoxide causes arrhythmias (2-10). Few carefully controlled double-blind studies exist with adequate control monitoring periods to assess spontaneous variability of arrhythmias in the control period. The purpose of double-blind study was to ascertain whether carbon monoxide exposure leading to elevated venous carboxyhemoglobin concentrations has an arrhythmogenic effect in patients with coronary artery disease. (Copyright (c) 1990 American College of Physicians.)