Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Ninety Day Inhalation Toxicity Study of Hydrogen Chloride Gas in B6C3F1 Mice, Sprague-Dawley Rats and Fisher-344 Rats with Cover Letter dated 05/06/85 and EPA Receipt Letter.
CORP Author Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Jun 1985
Year Published 1985
Report Number FYI-OTS-0685-0414-IN;
Stock Number OTS-0000414-0
Additional Subjects Inhalation ; Toxicity ; Exposure ; Mice ; Rats ; Procedures ; Pathology ; Monitoring ; Body weight ; Food consumption ; Control groups ; Hydrogen chloride gas ; B6C3F1 mice ; Sprague-Dawly rats ; Fisher-344 rats
Library Call Number Additional Info Location Last
NTIS  OTS-0000414-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 9p
A 90-day inhalation toxicity study using B (sub 6) C (sub 3) F (sub 1) mice, Sprague-Dawley (CD) rats and Fischer-344 (CDF) rats (exposed simultaneously in the same chambers) was conducted with hydrogen chloride gas. Three groups, each consisting of 31 males and 21 females of each species/strain, were designated as groups T-I, T-II and T-III and exposed to atmospheres of hydrogen chloride as target concentrations of 10 ppm, 20 ppm, and 50 ppm, respectively. After the fourth exposure, 15 males and females per group per species/strain were sacrificed. In addition, a control group (UC) consisting of 31 males and 21 females of each species/strain was exposed to clean air only and was handled in a manner similar to that of the test animals. The duration of exposure was 6 hours per day, 5 days per week for 90 days. Initial exposures for interim sacrifice animals and each species/strain were staggered to accommodate necropsy scheduling.