This document provides the health effects basis to be considered in establishing the Maximum Contaminant Level Goals (MCLG). To achieve this objective, data on pharmacokinetics, human exposure, acute and chronic toxicity to animals and humans, epidemiology and mechanisms of toxicity are evaluated. Specific emphasis is placed on literature data providing dose-response information. While the literature search and evaluation performed in support of this document has been comprehensive, only the reports considered most pertinent in the derivation of the MCLG are cited in the document. The comprehensive literature data base in support of this document includes information published up to 1986; however, more recent data have been added during the review process, and final revisions updating this document were made.