One of the clean product research projects being funded by the EPA's Pollution Prevention Research Branch in Cincinnati, Ohio, involves evaluating the possibility of dramatic reductions in hazardous waste and toxic chemical exposure associated with commercial products. By identifying priority products for substitution and evaluating the feasibility of safe substitutes for those products, this project can be an important shift toward preventing toxic chemical pollution at the source. The paper describes the project's objectives and gives a brief description of the approach the University of Tennessee (Waste Management Institute) plans to take to accomplish the objectives. The project started in September 1990 and will continue for three years.