| Main Title |
Mechanisms of TCDD-Induction of Cleft Palate: Insights from In vivo and In vitro Approaches. |
| Author |
Abbott, B. D. ;
Diliberto, J. J. ;
Birnbaum, L. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/442; |
| Stock Number |
PB93-141414 |
| Additional Subjects |
Teratogenic compounds ;
Toxicology ;
Cleft palate ;
Hydrocortisone ;
Tretinoin ;
Growth substances ;
Tetrachlorodibenzodioxin ;
Cultured cells ;
Embryos ;
Congenital abnormalities ;
Fetal development ;
In vivo analysis ;
Palate ;
Mice ;
Cell differentiation ;
In vitro analysis ;
Reprints ;
TCDD
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-141414 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Tetrachlorodibenzo-p-dioxin (TCDD) induced cleft palate (CP) in C57BL6N embryos by altering proliferation and differentiation of palatal medial epithelial cells. In palatal organ culture, concentration-dependent effects on medial epithelial cells occurred. The mechanism of TCDD activity appears to involve growth factor expression and may interact with retinoic acid and glucocorticoid pathways. |
