Record Display for the EPA National Library Catalog


Main Title 'Neanthes arenaceodentata' (Polychaeta: Annelida), a Proposed Cytogenetic Model for Marine Genetic Toxicology.
Author Pesch, Gerald G. ; Pesch, Carol E. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Year Published 1981
Report Number EPA-600/J-80-233 ;ERLN-J132;
Stock Number PB81-184715
Additional Subjects Toxicology ; Annelida ; Chromosomes ; Models ; In vivo analysis ; Concentration(Composition) ; Reprints ; Neanthes arenaceodentata ; Sister chromatid exchange ; Mitomycin ; Cytogenetics
Library Call Number Additional Info Location Last
NTIS  PB81-184715 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
Genetic toxicants are present in polluted marine environments and may represent a long-term threat to populations of marine organisms. This paper presents details of an in vivo application of sister chromatid exchange (SCE) analysis to a marine polychaete worm Neanthes arenaceodentata. This species exhibits a dose response to mitomycin C (MMC) at concentrations comparable to those eliciting responses in in vivo mammalian systems. A dose of 5 x 10 to the minus 7th power mol/L MMC increased the rate of SCE from a baseline frequency of 0.14/chromosome to 0.5/chromosome. The chromosomes of N. arenaceodentata may provide a useful model for identifying and studying the effects of genetic toxicants in marine environments.