| Contents Notes |
Access to sequence and literature databases -- Pairwise sequence alignment -- Basic Local Alignment Search Tool (BLAST) -- Advanced BLAST searching -- Genome-wide analysis of gene expression -- Gene expression: microarrays -- Protein analysis and proteomics -- Protein structure -- Multiple sequence alignment -- Molecular phylogeny -- Completed genomes and the tree of life -- Completed genomes: viruses -- Completed genomes: bacteria and archaea -- Eukaryotic genomes: fungi -- Eukaryotic genomes: from parasites to primates -- The human genome -- Human disease. Bioinformatics and Functional Genomics provides a broad-based introduction to bioinformatics by following three real-world examples throughout the book: retinol-binding protein, breast cancer, and a calcium binding site C2. The author emphasizes the use of computational tools and databases to study connections between the structure of proteins and genes to function, development, evolution, and disease. Readers learn real skills, such as how to analyze genes and proteins, how to make trees using phylogenetic software, how to extract data, and how to identify genes and proteins implicated in diseases. |
