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RECORD NUMBER: 45 OF 82

Main Title Initial Submission: Letter to USEPA Reporting Results of Guinea Pig Maximization Test on (Confidential Information), dated 12/02/99 (Sanitized).
CORP Author ;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 6 Dec 1999
Year Published 1999
Report Number 8EHQ-1199-14603S;
Stock Number OTS-0559850
Additional Subjects Toxicity ; Erythema ; Guinea pigs ; Laboratory animals ; Concentration ; Skin sensitization ; Edema ; Dermal irritation responses ; Lubricant additive components ; Guinea Pig Maximization Test
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  OTS-0559850 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract
The skin sensitization potential of the test material was evaluated in the Guinea Pig Maximization Test. At 48 hours following challenge application of the undiluted test material, 60% of the treated animals exhibited a positive reaction ranging from moderate to severe erythema. Edema was also noted in four out of twenty treated animals during the post-challenge observation. For the rechallenge, the test material was diluted to 50 wt% in olive oil to reduce the dermal irritation responses noted during challenge. At 48 hours post- rechallenge, 30% of the treated animals exhibited a positive reaction ranging from slight to moderate erythema. Based on the conditions of this test and the results of the challenge and rechallenge, the test material displayed moderate skin sensitization potential.