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Main Title Effects of PCB (Aroclor (Trade Name) 1254) on Non-Specific Immune Parameters in Rhesus ('Macaca mulatta') Monkeys.
Author Tryphonas, H. ; Luster, M. I. ; White, K. L. ; Naylor, P. H. ; Erdos, M. R. ;
CORP Author Health and Welfare Canada, Ottawa (Ontario). Health Protection Branch. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Medical Coll. of Virginia, Richmond. ;George Washington Univ. Medical Center, Washington, DC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/J-92/324;
Stock Number PB92-232867
Additional Subjects Polychlorobiphenyl compounds ; Macaca mulatta ; Aroclors ; Immunity ; Toxicity ; Body weight ; Interferons ; Hemolysis ; Tumor necrosis factor ; Natural killer cells ; Complement ; Reprints ; Thymosins
Library Call Number Additional Info Location Last
NTIS  PB92-232867 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The effects of low level, chronic polychlorinated biphenyl -- Aroclor 1254 -- (PCB) exposure were investigated on non-specific immune parameters in female rhesus (Macaca mulatta) monkeys. Five groups of monkeys were orally administered with PCB at concentrations of 0, 5, 20, 40 or 80 micrograms/kg bw/day. Immunotoxicity testing was initiated after 55 months of exposure. The serum hemolytic complement activity in all PCB treated groups was significantly higher (P<0.05) than that in the control group. A statistically significant dose-related increase in natural killer cell activity was evident at the 75 : 1 effector to target cell ratio. Similarly, a statistically significant dose-related increase was noted for thymosin alpha-1 levels but not for thymosin beta-4 levels. Statistically significant increased interferon levels were noted in the 20 and 80 micrograms/kg groups compared with the control group while the levels in the 40 micrograms/kg group were decreased significantly compared with the control group. The production of tumor necrosis factor by monocytes in the PCB treated groups was not different to that in the control group. The results indicated that long term exposure to PCB modulate several non-specific immune parameters. (Copyright (c) 1991 International Society for Immunopharmacology.)