| Main Title |
Time-Dependent Neurobiological Effects of Colchicine Administered Directly into the Hippocampus of Rats (Journal Version). |
| Author |
Tilson, H. A. ;
Rogers, B. C. ;
Grimes, L. ;
Harry, G. J. ;
Peterson, N. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/419; |
| Stock Number |
PB89-105944 |
| Additional Subjects |
Neurobiology ;
Colchicine ;
Hippocampus ;
Animal behavior ;
Avoidance learning ;
Pathology ;
Dynorphin ;
Methionine enkephalin ;
Alkaloids ;
Motor activity ;
Startle reaction ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105944 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Rats were given bilateral injections of colchicine into the dorsal and ventral hippocampus. Behavioral, neurochemical and histopathological measurements were taken up to 12 weeks after surgery. Colchicine produced a consistent increase in spontaneous motor activity, enhanced acoustic startle reactivity, and accelerated acquisition of two-way shuttle box avoidance, but did not affect reactivity to a noxious thermal stimulus. Measurement of dynorphin in the hippocampus indicated that colchicine rapidly depleted this neuropeptide, which is thought to be contained preferentially in the mossy fibers of granule cells of the hippocampus. Colchicine also decreased metenkephalin in the hippocampus, but the magnitude of the change (22%) was less than that (89% depletion) observed for hippocampal dynorphin. Examination of hippocampal morphology using light microscopic techniques indicated that colchicine caused approximately 60% degeneration of granule cells in the hippocampus. (Copyright (c) 1987 Elsevier Science Publishers B.V.) |
