Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Neurotoxic Effects of Colchicine.
Author Mundy, W. R. ; Tilson, H. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher cApr 90
Year Published 1990
Report Number EPA/600/J-90/325;
Stock Number PB91-149658
Additional Subjects Toxicology ; Nervous system ; Colchicine ; Hippocampus ; Neurons ; Axons ; Mitosis ; Tubulins ; Rats ; Reprints ; Dentate gyrus
Library Call Number Additional Info Location Last
NTIS  PB91-149658 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 12p
Neurotoxicants have found increasing use as tools to study the structure and function of the central nervous system. One class of compounds which block mitosis and disrupt axoplasmic transport includes colchicine, a chemical which is highly toxic to certain neuronal populations. Colchicine administered directly into the hippocampus of rats results in the preferential destruction of dentate gyrus granule cells without affecting the surrounding pyramidal cells. Injection of colchicine into other brain areas also destroys neurons but with less selectivity than is observed in the hippocampus. The neurotoxicity of colchicine appears to be related to the ability to bind to tubulin, although its exact mechanism remains to be elucidated. (Copyright (c) 1990 Intox Press, Inc.)