Record Display for the EPA National Library Catalog


Main Title Report of the EPA Workshop on the Development of Risk Assessment Methodologies for Tumor Promoters : project summary /
Other Authors
Author Title of a Work
Connery, Jan,
Publisher U.S. Environmental Protection Agency, Office of Health and Environmental Assessment,
Year Published 1988
Report Number EPA/600-S9-87-013
OCLC Number 898083021
Subjects Cocarcinogens--Research--Congresses ; Tumors--Genetic aspects--Research--Congresses ; Genetic engineering--Risk assessment--Congresses
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-S9-87-013 In Binder Headquarters Library/Washington,DC 10/03/2018
ELBD ARCHIVE EPA 600-S9-87-013 In Binder Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
Collation 2 pages ; 28 cm
"EPA/600-S9-87-013." "August 1988." Caption title. At head of title: Project Summary.
Contents Notes
At a workshop sponsored by the EPA Office of Research and Development in February 1987, thirteen expert panelists discussed research needed to support the development of risk assessment methodologies for tumor promoters. The panelists exchanged current data on promotion, identified data gaps, and formulated general and specific research recommendations. Available data suggest that there are probably at least three stages of carcinogenesis - initiation, promotion and progression - and that there are agents that are associated predominantly with these three stages. The panelists agreed that the mechanism of promotion is not currently understood, and they suggest that there may be several different mechanisms of promotion. Available data suggest that promotion is substantially different from initiation and that traditional risk assessment models for carcinogens are not appropriate for promoters. The panelists agreed that not enough data are currently available to assess the risks of promoters and that substantial research is needed in several areas, including: mechanisms of initiation, promotion and progression; the behavior of promoters in humans, especially epidemiological studies; development and validation of statistical models for initiation/promotion systems; the behavior of promoters in organs other than the skin and the liver; interspecies differences in promotion; expansion of the chemical data base for known and potential promoters; synergism among promoters; and development validation of in vitro screening models for known experiment promoters.