Record Display for the EPA National Library CatalogRECORD NUMBER: 25 OF 36
|Main Title||Letter from Exxon Co. to USEPA Regarding Enclosed Information on the 12-Week Vapor Exposure Study Concerning Isopar C, Isoparaffinic Hydrocarbon Solvent and Varsol 40 with Attachments.|
|CORP Author||Exxon Chemical Co., Houston, TX. Technology Div.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||3 Oct 1979|
|Additional Subjects||Vapors ; Solvents ; Hydrocarbons ; Toxicity ; Females ; Mortality ; Body weight ; Hematology ; Clinical chemistry ; Mice ; US EPA ; Kidney disease ; Inhalation ; Exposure ; Cell membranes ; Chemicals ; Evaluation ; Lesions ; Isoparaffinic hydrocarbon solvent ; Exxon Corporation ; Isopar C ; Varsol 40|
The submission presents a summary of the final results from 12-week inhalation toxicity studies of ISOPAR C and VARSOL 40 solvents in male and female rats. Evidence of kidney damage is reported for male rats exposed to the solvents. Both ISOPAR C and VARSOL 40 appear to produce typical toxic nephrosis (degeneration of the epithelial cells of the kidney tubules without damage to the basement membrane). Mercury, dichromate, uranium, chloroform, carbon tetrachloride, dioxane, and many other chemicals produce similar lesions in the kidney.