Record Display for the EPA National Library Catalog


Main Title Frequency and Nature of Specific-Locus Mutations Induced in Female Mice by Radiations and Chemicals: A Review.
CORP Author Oak Ridge National Lab., TN. Biology Div.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;Department of Energy, Washington, DC.
Publisher c1992
Year Published 1992
Report Number DE-AC05-84OR21400; EPA/600/J-93/177 ; OHEA-R-480
Stock Number PB93-194447
Additional Subjects Mutations ; Radiation doses ; Mutagens ; Chromosome mapping ; Females ; Mice ; DNA damage ; Oocytes ; Mosaicism ; Reprints ; Female genetic risk
Library Call Number Additional Info Location Last
NTIS  PB93-194447 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 23p
The inducibility of heritable mutations in female mammals has been measured in the mouse specific-locus test (SLT). For radiation-induced mutations, a large body of data has been accumulated. However, relatively few SLT studies in females have been conducted with chemicals. Of only 5 chemicals so far explored for their effect in oocytes, two, ethylnitrosourea (ENU) and triethylenemelamine (TEM), and possibly a third, procarbazine hydrochloride (PRC), are mutagenic with at least one of these (ENU) mutagenic in arrested as well as maturing oocytes. However, the mutation rate is, in each case, lower than for treated male germ cells. By contrast, ENU-induced mutation yield for the maternal genome of the zygote is an order of magnitude higher than that for the zygote's paternal genome or for spermatogonia. A high proportion of mutants derived from chemical treatment of oocytes are mosaics, probably owing to lesions affecting only one strand of the DNA.