| Main Title |
Micronuclei and Other Nuclear Anomalies in Buccal Smears: A Field Test in Snuff Users. |
| Author |
Tolbert, P. E. ;
Shy, C. M. ;
Allen, J. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/445; |
| Stock Number |
PB93-141448 |
| Additional Subjects |
Mouth ;
Carcinogenesis ;
Tobacco ;
Micronucleus tests ;
Smokeless tobacco ;
Field tests ;
Risk factors ;
Genetic markers ;
Epithelial cells ;
Chromosome aberrations ;
Public health ;
Epidemiologic methods ;
Reprints ;
Buccal smears ;
Snuff
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-141448 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
A revised protocol for the exfoliated cell micronucleus assay was field-tested in a population exposed to a genotoxic agent at levels associated with a significant increase in cancer risk. The standard assay involves microscope examination of epithelial smears to determine the prevalence of micronucleated cells with separate scoring of other nuclear anomalies associated with cytotoxicity and genotoxicity. Prevalence of micronucleated cells was elevated in the snuff users compared to the non-users. The pattern of relative frequencies of several nuclear anomalies provided strong evidence of a cytotoxic effect of snuff. |
