Record Display for the EPA National Library CatalogRECORD NUMBER: 6 OF 16
|Main Title||Evaluation of the potential carcinogenicity of chromium and hexavalent chromium compounds /|
|CORP Author||Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.|
|Publisher||U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;|
|Report Number||EPA/600/8-91/093; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-057|
|Subjects||Aromatic compounds--Carcinogenicity ; Chromium--Carcinogenicity ; Hexavalent chromium--Carcinogenicity|
|Additional Subjects||Carcinogens ; Toxicity ; Chromium inorganic compounds ; Humans ; Animals ; Carcinogenicity tests ; Dose-response relationships ; Risk assessment ; CAS 7440-47-3 ; CAS 7789-09-5 ; CAS 7789-98-9 ; CAS 13765-19-0 ; CAS 1333-82-0 ; CAS 14307-35-8 ; CAS 7778-50-9 ; CAS 7789-00-6 ; CAS 10588-01-9 ; CAS 7775-11-3 ; CAS 7789-06-2|
|Collation||38 pages ; 28 cm|
Hexavalent chromium compounds are human carcinogens, classified as weight-of-evidence Group A (based on chromate production workers and animal data which indicates that inhaled hexavalent chromium compounds are carcinogenic) under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Sufficient. As stated in the U.S. EPA Health Assessment Document on chromium and compounds, metallic chromium is biologically inert and has not been reported to produce tumors in man or animal models. The no data are available on the carcinogenicity of metallic chromium. The potency factor (F) for hexavalent chromium is estimated to be 389/(mg/kg/day) (based on epidemiological data for the inhalation of hexavalent chromium by chromate workers), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, all of the hexavalent chromium compounds are assigned a HIGH hazard ranking for the purposes of RQ adjustment.
Cover title. "June 1988." Includes bibliographical references. Microfiche.