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Main Title Long-Term Effects of Triethylenemelamine Exposure on Mouse Testis Cells and Sperm Chromatin Structure Assayed by Flow Cytometry.
Author Evenson, D. P. ; Baer, R. K. ; Jost, L. K. ;
CORP Author South Dakota State Univ., Brookings. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-810991; EPA/600/J-89/374;
Stock Number PB90-216250
Additional Subjects Testis ; Toxicity ; Graphs(Charts) ; Mice ; Exposure ; Body weight ; Alkylating agents ; Reprints ; Spermatozoa ; Chromatin ; Flow cytometry ; Triethylenemelamine ; Mutagenicity tests ; Organ weight ; Acridine orange
Library Call Number Additional Info Location Last
NTIS  PB90-216250 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
The toxic and potentially mutagenic actions of triethylenemelamine (TEM) on mouse body and testis weights, testicular cell kinetics, sperm production, sperm head morphology, and sperm chromatin structure were assessed in two experiments. The first experiment examined effects of four dose levels of TEM, assayed 1, 4, and 10 wk after toxic exposure. In the second study, effects from five dosage levels were measured at 1, 4, and 10 wk, and the highest dosage level was evaluated over 44 wk. TEM produced an expected dose related loss of spermatogenic activity and subsequent recovery as determined by dual-parameter (DNA, RNA) flow cytometry (FCM) measurements of testicular cells.