Record Display for the EPA National Library Catalog


Main Title In vitro Assessment of Gamete Integrity.
Author Perreault-Darney, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch.
Publisher c1990
Year Published 1990
Report Number EPA/600/D-90/247;
Stock Number PB91-162610
Additional Subjects Spermatozoa ; Ovum ; Fertility ; Xenobiotics ; Toxicity ; In vitro analysis ; Deoxyribonucleic acids ; Chromatin ; DNA damage ; Aneuploidy ; Mutation ; Sperm motility ;
Library Call Number Additional Info Location Last
NTIS  PB91-162610 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Drugs and xenobiotics can compromise reproductive function by impairing gamete physiology and thereby blocking fertilization, or by damaging gamete DNA or chromatin and thereby causing pregnancy failure or birth defects. Standard measures of gamete integrity, such as morphology, motility (sperm), or fertilizing ability, while useful in identifying and characterizing adverse effects, may not identify genetic damage in the gametes. To better assess gamete integrity, methods capable of detecting DNA or chromosomal damage in individual sperm or egg cells are needed. The report summarizes recent advances in in vitro technologies for assessing both the pathophysiologic and genetic integrity of gametes with emphasis on the latter.