Record Display for the EPA National Library Catalog


Main Title Effects of low level carbon monoxide exposure : blood lipids and coagulation parameters /
Author Brinkhous, K. M. ; Brinkhouse., K. M.
CORP Author North Carolina Univ., Chapel Hill. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA/600/1-77/032; EPA-68-02-1281
Stock Number PB-269 340
OCLC Number 42838161
Subjects Carbon monoxide--Physiological effect
Additional Subjects Carbon monoxide ; Toxicity ; Blood coagulation ; Lipids ; Dosage ; Exercise(Physiology) ; Fibrin ; Blood ; Concentration(Composition) ; Males ; Experimental data ; Exposure ; Physiological effects ; Cholesterol ; Glycerides ; Hematocrit ; Platelets ; Prothrombin ; Thromboplastin ; Thrombin ; Cigarette smoking ; Carbonylhemoglobin ; Air pollution effects(Humans) ; Blood coagulation factor VIII ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-77-032 Headquarters Library/Washington,DC 04/14/2014
EJBD  EPA 600-1-77-032 c.1 Headquarters Library/Washington,DC 05/27/2014
EJED  EPA 600/1-77/032 OCSPP Chemical Library/Washington,DC 07/01/2005
EKBD  EPA-600/1-77-032 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD  EPA 600-1-77-032 AWBERC Library/Cincinnati,OH 09/02/2016
NTIS  PB-269 340 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iv, 23 pages ; 28 cm.
The study examined the effects of carbon monoxide (CO) in 50 and 100 ppm doses on response to treadmill exercise, blood coagulation and blood lipids in normal men. Twenty-three men were exposed to CO or to air in a double-blind protocol. After exposure, each underwent a graded exercise treadmill test which was terminated at 85% maximal heart rate. Blood for measurement of carboxyhemoglobin (COHb), hematocrit, platelet count, prothrombin time, partial thromboplastin time, thrombin time, fibrin split products, factor VIII, platelet aggregation, serum cholesterol and triglycerides was drawn at baseline, preexercise and postexercise. COHb did not change on air days but reached a mean of 2.17% on 50 ppm days and 4.15% on 100 ppm days. The mean duration of exercise was 19 sec shorter on CO days than on air days (f = 4.93). The greatest effect was on 100 ppm days (f = 8.00). Coagulation parameters and cholesterol and triglyceride measurements were not significantly affected by CO exposure.
"EPA-600/1-77-032." EPA contract no. 68-02-1281; EPA project officer: Edward D. Haak, Jr.