| Main Title |
Acute and Subchronic Toxicity in Rats of Trans-1,2-Dichloroethylene in Drinking Water (Journal Version). |
| Author |
Hayes, J. R. ;
Condie, L. W. ;
Egle, J. L. ;
Borzelleca, J. F. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/389; |
| Stock Number |
PB89-101117 |
| Additional Subjects |
Toxicity ;
Toxic substances ;
Potable water ;
Dichloroethylenes ;
Histology ;
Organ weight ;
Laboratory animals ;
Chlorine organic compounds ;
Exposure ;
Reprints ;
Health effects ;
Ethene/trans-dichloro ;
CAS 156-60-5 ;
Risk assessment
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-101117 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Trans-1,2 dichloroethylene has been identified in drinking water at a concentration of approximately 1.0 micrograms/liter. The study provides data on the effects of trans-1,2 dichloroethylene in drinking solutions. The acute oral LD50 in male and female Charles River rats was found to be 7902 mg/kg for males and 9939 mg/kg for females. Male and female Charles River rats receive theoretical daily doses of 500, 1500 and 3000 mg/kg b.w./day for 90 consecutive days. There were no compound-related deaths. There were no consistently significant dose-related effects on any of the hematological, serological or urinary parameters evaluated. There were dose-dependent increases in the liver and kidney weights and ratios. There were no compound-related gross or histological effects. These data suggest that exposure of humans to reported levels of trans-1,2 dichloroethylene does not constitute a serious health hazard. |
