| Main Title |
Draft Criteria Document for 1,2, Dichloropropane. |
| CORP Author |
Environmental Protection Agency, Washington, DC. Science Advisory Board. |
| Publisher |
9 Mar 88 |
| Year Published |
1988 |
| Report Number |
SAB/EHC-88/018; |
| Stock Number |
PB89-114508 |
| Additional Subjects |
Chlorine aliphatic compounds ;
Water pollution abatement ;
Potable water ;
Carcinogens ;
Public health ;
Laboratory animals ;
Risk assessment ;
Safe Drinking Water Act
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-114508 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
The Halogenated Organics Subcommittee of the EPA Science Advisory Board's Environmental Health Committee conducted an independent scientific review of the Office of Drinking Water's Draft Criteria Document for 1,2 Dichloropropane. The Subcommittee unanimously concluded that the drinking water equivalent level should not be based on the non-carcinogenic endpoints of the National Toxicology Program's 1986 bioassay in male rats. It offered five reasons for this conclusion: (1) the dose of 62 mg/kg bw/day represents a no-observed-effect-level for cancer in male rats; (2) the endpoints of survival, body weight organs and tissues are not sufficiently sensitive; (3) histological lesions were observed in the testes of some male rats given the 62 mg dose; (4) evidence indicated that the chemical may be a male reproductive toxic; and (5) the NTP bioassay was not designed to supply data for derivation of a drinking water equivalent level. |
