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RECORD NUMBER: 9 OF 15

Main Title In vitro Studies of Chemical Effects on Gap-Junctional Communication: Role of Biotransformation in Toxicant Detection and Use of Assays in Risk Assessment.
Author Malcolm, A. R. ; Mills, L. J. ; Robson, D. L. ;
CORP Author Environmental Research Lab., Narragansett, RI. ;Science Applications International Corp., Narragansett, RI.
Publisher c1990
Year Published 1990
Report Number ERLN-981 ;EPA/600/J-90/024;
Stock Number PB90-217670
Additional Subjects Toxicity ; In vivo analysis ; Reproduction(Biology) ; In vitro analysis ; Bioassay ; Reprints ; Biotransformation ; Toxic substances ; Intercellular junction ; Risk assessment ; Chinese hamsters ; Cyclamates
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Status
NTIS  PB90-217670 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract
A correlation is emerging between the capacity of chemical substances to inhibit gap-junctional intercellular communication in vitro and their capacity to induce reproductive and developmental dysfunction, neurotoxicity and tumor promotion in vivo. A practical issue in identifying chemicals affecting gap-junctional communication in vitro is the role of metabolic products. Phenol, a weak promoter of mouse skin tumors, failed to inhibit gap-junctional communication between Chinese hamster V79 lung fibroblasts; however, five metabolites of phenol suppressed gap-junctional communication in a concentration-related manner. Sodium cyclamate, a possible promoter of bladder cancer in rats, weakly inhibited gap-junctional communication in the same assay; however, three metabolites were stronger inhibitors than sodium cyclamate. Thus, some metabolic products may show activity when parent compounds do not or may show greater activity than parent compounds.