Record Display for the EPA National Library Catalog

RECORD NUMBER: 510 OF 1711

Main Title Health assessment document for epichlorohydrin : final report.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. ;Dynamac Corp., Rockville, MD.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1984
Report Number EPA-600/8-83-032F
Stock Number PB85-132363
OCLC Number 12417045
Subjects Epichlorohydrin--Toxicology
Additional Subjects Epichlorohydrin--Toxicology ; Public health ; Assessments ; Toxicology ; Metabolism ; Environmental surveys ; Physical properties ; Dosage ; Chemical properties ; Risk ; Laboratory animals ; Exposure ; Air pollution ; Toxic substances ; Cancer
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001BUD.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EHAM  EPA-600/8-83-032F Region 1 Library/Boston,MA 05/25/2016
EJED  EPA 600/8-83-032F OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/8-83-032F Research Triangle Park Library/RTP, NC 03/19/2004
ELBD ARCHIVE EPA 600-8-83-032F Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
ERAD  EPA 600/8-83-032F Region 9 Library/San Francisco,CA 02/26/2013
ESAD  EPA 600-8-83-032F Region 10 Library/Seattle,WA 07/29/2005
NTIS  PB85-132363 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xvi (various pagings) : illustrations ; 28 cm
Abstract
This document summarizes current scientific information regarding the health and environmental effects of epichlorohydrin. Specifically, this document discusses the following topics: physical and chemical properties of epichlorohydrin; environmental occurrence; metabolism and toxicology; and factors most relevant to assessing quantitative health risks, particularly risk of cancer. Epichlorohydrin is moderately toxic by oral, dermal, and inhalation routes of exposure. Long-term animal studies provide evidence that epichlorohydrin is a weak contact carcinogen which appears to produce no metastases. Epichlorohydrin should be considered a potential human carcinogen (IARC category 2B). Epichlorohydrin causes gene and chromosomal mutations in vitro and in vivo, and has been shown to be clastogenic in human lymphocytes. Epichlorohydrin was not teratogenic in mice, rats, or rabbits, but was embryotoxic at doses which were toxic to the pregnant mouse. Transient infertility was observed in male rats exposed to epichlorohydrin. Epichlorohydrin is not expected to persist in air, water, or soil because of hydrolysis. The atmospheric residence time was calculated to be 5.8 days.
Notes
"December 1984." Includes bibliographical references.