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Main Title Use of physiologically based pharmacokinetic (PBPK) models to quantify the impact of human age and interindividual differences in physiology and biochemistry pertinent to risk (final report) [electronic resource] .
Author Lipscomb, J. C. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. National Center for Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment,
Year Published 2006
Report Number EPA/600/R-06/014A
Stock Number PB2006-110280
Subjects Research ; Risk assessment ; Biochemistry ; Physiology
Additional Subjects Pharmacokinetics ; Physiologically-based pharmacokinetic modeling ; Tables (Data) ; Case studies ; Chemical metabolism ; Human variability ; Enzyme content ; Human health ; Risk assessment ; Research protocols ;
Internet Access
Description Access URL
http://oaspub.epa.gov/eims/eimscomm.getfile?p_download_id=458590
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100CQU6.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB2006-110280 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 online resource (various pagings) : ill., charts ; digital, PDF file
Abstract
This report is intended to communicate a framework developed for the extrapolation and integration of in vitro-derived measures of chemical metabolism, including those that define human interindividual variability. It presents instruction on the most useful measures of chemical metabolism constants and guides the proper interpretation of differences in enzyme content, so that risk assessors who summarize these types of data for inclusion in human health risk assessment make optimal use of the available information. Likewise, the demonstration of the approach and data requirements will guide the construction of laboratory research protocols which result in the development of data optimally relevant to informing the true nature of human variability. Finally, this approach is communicated through instruction and demonstration of the approach and framework; it is useful to those who develop and evaluate PBPK models intended to address human variability for risk assessment application.
Notes
Title from title screen (viewed on 4/4/11)