The purpose of the manual is to provide guidance to prevent spills of hazardous substances in fixed facilities that produce substances from raw or starter materials, store the substances, or transfer the substances to and from transportation terminals. The emphasis is on smaller-sized chemical manufacturing facilities. The manual consists of seven sections and an Appendix: (1) Introduction: (2) Manual of practice; (3) Hazardous substances and their characteristics; (4) Fixed facilities; (5) Facility spill prevention practices; (6) Preventive engineering practices; and (7) Bibliography. Section 1 contains the purpose and an overview of the manual. Section 2, the manual proper, deals with the preparation of a Facility Spill Prevention Master Plan and makes use of Sections 3, 4, 5, and 6. Section 3 contains a listing of all hazardous substances under consideration, with their physical behavior on release to air, water and ground, and their specific hazards. Section 4 lists the fixed facility equipment elements that would interact with hazardous substances. Section 5 lists the various facility spill prevention practices, including organization, risk identification, material compatibility, preventive maintenance, good housekeeping, security and training. Section 6 details the preventive engineering practices such as monitoring and secondary containment of storage vessels, fire protection systems, alarm systems, valving and venting, drainage control, waste treatment, etc. Section 7 lists the sources used in preparing the manual. The appendix contains descriptions of fixed facility chemical processing equipment components, from which a checklist of equipment items interacting with hazardous substances can be derived for use in preparing a Spill Prevention Plan.