Record Display for the EPA National Library Catalog

RECORD NUMBER: 31 OF 63

Main Title Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat.
Author Schut, H. A. J. ; Daniel, F. B. ; Schenck, K. M. ; Loeb, T. R. ; Stoner, G. D. ;
CORP Author Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/164;
Stock Number PB85-146801
Additional Subjects Environmental surveys ; Biochemistry ; Malignant neoplasms ; Toxicology ; Metabolism ; Deoxyribonucleic acids ; Bladders ; Amines ; Laboratory animals ; Dogs ; Monkeys ; Rats ; Aromatic compounds ; Industrial hygiene ; Chemical bonds ; Reprints ; Cancer ; Occupational safety and health ; Fluorene/acetyl-amino
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-146801 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract
It is concluded that bladder explants of the human, dog, monkey, hamster, and rat metabolize AAF mainly to ring-hydroxylated products, but also form small amounts of the proximate carcinogenic metabolite N-hydroxy-AAF. Neither the overall binding of AAF to bladder DNA, nor the formation of specific AAF-DNA adducts is correlated with the relative susceptibilities of these five species to aromatic amine-induced urinary bladder carcinogenesis.