||Characterization of data variability and uncertainty : health effects assessments in the Integrated Risk Information System (IRIS) : in response to Congress, HR 106-379 /
||Environmental Protection Agency, Washington, DC. Office of Research and Development.
||U.S. Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development,
Ecological risk assessment ;
Health risk assessment
Environmental exposure pathway ;
Health effects ;
Risk assessments ;
Data bases ;
Health hazards ;
Dose-response relationships ;
Chemical composition ;
Information systems ;
Integrated Risk Information System(IRIS)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||20 p. ; 28 cm.
In response to a Congressional directive contained in HR 106-379 regarding EPA's appropriations for FY2000, EPA has undertaken an evaluation of the characterization of data variability and uncertainty in its Integrated Risk Information System (IRIS) health effects information database. Through consultation with EPA's Science Advisory Board, EPA developed and implemented a systematic plan to select a representative sample of chemical assessments in IRIS to be evaluated in-depth by an independent panel of experts for the extent to which EPA has documented uncertainty and variability. EPA conducted a screening evaluation on 10% percent of the IRIS summaries of chemical assessments completed during the period of 1988-1994 (52 of 522 pre-Pilot assessments) and all 15 Pilot/post-Pilot IRIS summaries and Toxicological Reviews (completed after 1995) for overall documentation of data variability and uncertainty. An EPA contractor then selected 16 assessments (IRIS summaries and support documents) for in-depth examination from the screening sample (8 of 52 pre-Pilot and 8 of 15 Pilot/post-Pilot). The contractor selected six independent experts (outside EPA) in the field of human health risk assessment, who performed this in-depth review.