Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Piperonyl Butoxide as a Tool in Aquatic Toxicological Research with Organophosphate Insecticides.
Author Ankley, G. T. ; Dierkes, J. R. ; Jensen, D. A. ; Peterson., G. S. ;
CORP Author Environmental Research Lab., Duluth, MN. ;AScI Corp., Duluth, MN.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/173;
Stock Number PB91-231415
Additional Subjects Toxicology ; Organophosphate insecticides ; Piperonyl butoxide ; Water pollution effects(Animals) ; Daphnia ; Cytochrome p-450 ; Metabolic activation ; Diazinon ; Malathion ; Methyl parathion ; Parathion ; Reprints ; Ceriodaphnia dubia
Library Call Number Additional Info Location Last
NTIS  PB91-231415 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/26/1991
Collation 9p
Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures. (Copyright (c) 1991 Academic Press, Inc.)