| Main Title |
Effects of heavy metals on the differentiation of metabolic pathways in the CNS / |
| Author |
O'Neill, John J. ;
van Rossum, George ;
Salgonicoff, Leon
|
| Other Authors |
|
| CORP Author |
Temple Univ., Philadelphia, PA. School of Medicine.;Health Effects Research Lab., Cincinnati, OH. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Researh Laboratory, |
| Year Published |
1982 |
| Report Number |
EPA/600/1-82/008; EPA-68-03-2381 |
| Stock Number |
PB82-249145 |
| Additional Subjects |
Central nervous system ;
Lead(Metal) ;
Tin ;
Toxicology ;
Rats ;
Laboratory animals ;
Brain ;
Spinal cord ;
Liver ;
Kidney ;
Concentration(Composition) ;
Bioassay ;
Metals ;
In vitro analysis ;
Metabolism ;
Heavy metals ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-249145 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
71 pages : illustrations ; 28 cm |
| Abstract |
The effects of lead and organotin on brain and spinal cord, liver or kidney in the developing or adult Sprague-Dawley and Wistar rat strains were investigated. Two concentrations of lead were present in drinking water: 200 parts per million or 600 parts per million as lead in lead acetate. Blood and tissue lead levels were also measured. Tissue slices prepared from kidney cortex of animals exposed to 200 or 600 ppm lead showed a respiration rate 15% less and ATP contents which were 30% less when compared with corresponding tissue from control animals. Lead treatment in vivo was found to have no significant effect on the ion and water contents of kidney cortex in contrast with results obtained when lead was added in vitro. The ability of kidney cortex slices to restore ion and water contents after incubation at 1C was also unimpaired after in vivo treatment. |
| Notes |
Caption title. "June 1982." "EPA-600/1-82-008." Microfiche. |
