Record Display for the EPA National Library Catalog
RECORD NUMBER: 24 OF 65| Main Title | Genetic Toxicology of Gene-Tox Non-Carcinogens (Journal Version). | |||||||||||
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| Author | Waters, M. D. ; Bergman, H. B. ; Nesnow, S. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Publisher | 1987 | |||||||||||
| Year Published | 1987 | |||||||||||
| Report Number | EPA/600/J-88/087; | |||||||||||
| Stock Number | PB89-109672 | |||||||||||
| Additional Subjects | Toxicology ; Bioassay ; Carcinogens ; Genetics ; Organic compounds ; Laboratory animals ; Chromosome abnormalities ; Evaluation ; Benzoin ; Caffeine ; Ethyl alcohol ; Malathion ; Maleic hydrazide ; Methotrexate ; Phenylene diamines ; Reprints ; Mutagenicity tests ; Neoplastic cell transformation ; Halothane ; Hycanthone methanesulfonate ; Naphthylamines ; Nitrophenylenediamines ; Caprolactam ; CAS 119-53-9 ; CAS 123-33-1 ; CAS 106-50-3 ; CAS 105-60-2 ; CAS 58-08-2 ; CAS 64-17-5 ; CAS 151-67-7 ; CAS 23255-93-8 ; CAS 134-32-7 ; CAS 99-56-9 ; CAS 121-75-7 ; CAS 59-05-01 | |||||||||||
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| Collation | 47p | |||||||||||
| Abstract | The Gene-Tox program evaluation of chemicals has identified 61 chemicals that have been tested in chronic rodent bioassays and found to be inactive. The genetic toxicology data of these 61 non-carcinogens is reviewed and summarized. The genetic toxicity of 12 chemicals with sufficient data is discussed in detail. A new technique for the evaluation of multiple test data, the Genetic Activity Profile, has been applied to the last 6 chemicals, allowing the qualitative and quantitative information to be compared collectively. In the evaluation of the genotoxic effects of these non-carcinogens, a number of discrepancies between the results from genetic toxicity bioassays and chronic rodent bioassays have been uncovered. These discrepancies are discussed in light of current knowledge on the strengths and weaknesses of both genetic toxicity bioassays and chronic rodent bioassays. |