Record Display for the EPA National Library Catalog


Main Title Inhibition of Intercellular Communication between Mouse Hepatocytes by Tumor Promoters.
Author Ruch, R. J. ; Klaunig, J. E. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo.
Year Published 1987
Report Number EPA/600/J-87/016;
Stock Number PB87-196218
Additional Subjects Carcinogens ; Pharmacology ; Methyl sulfoxide ; Cytology ; Liver ; DDT ; Phenobarbital ; Ribonucleic acids ; Neoplasms ; Uridine ; Cells ; Reprints ; Cell communication ; Aroclors ; Benzene hexachloride ; Dimethyl sulfoxide
Library Call Number Additional Info Location Last
NTIS  PB87-196218 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Tumor promoters can inhibit gap junction-mediated intercellular communication in cultured cells. The authors evaluated the effects of tumor promoters on intercellular communication between B6C3F1 mouse hepatocytes in primary culture. Intercellular communication between donor and recipient hepatocytes was detected as an increase in autoradiographic grains over recipient cells in contact with donor cells, indicating the passage of labeled nucleotides from donor to recipient hepatocytes. Intercellular communication in untreated and solvent vehicle treated hepatocytes was detected in approximately 80% of the donor-contacting recipients after 8-12 hr culture. Phenobarbital, DDT, Aroclor 1254, lindane, and TPA significantly decreased hepatocyte intercellular communication in a dose-dependent manner. (Copyright (c) 1987 by Academic Press, Inc.)