Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Activation of Aromatic Amines to Mutagens by Bovine Bladder and Liver Cells.
Author Oglesby, Linda ; Hix-Baker, Cathy ; MacNair, Pat ; Sieg, Marianne ; Snow, Linda ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83/014;
Stock Number PB83-219584
Additional Subjects Amines ; Toxicology ; Aromatic compounds ; Cattle ; Bladder(Urinary) ; Hamsters ; Bacteria ; Laboratory animals ; Mutagens ; Reprints ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB83-219584 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
A bovine bladder cell-mediated mutagenesis system using Chinese hamster V79 cells and Samonella typhimurium as target organisms was developed to investigate the capacity of the bladder urothelium to activate chemical carcinogens. Bovine bladder epithelial cells can activate the aromatic amines AF and 4-ABP to intermediates which mutate V79 cells and S. typhimurium TA 98 and TA 100. DMBA was mutagenic to V79 cells but not detectably mutagenic to either Salmonella strain with bladder cell activation. The chemicals tested were not mutagenic to either target organism in the absence of bladder cells.