Cardiac Cytoarchitecture in Health and Disease -- In Vitro Tools for Quantifying Structure-Function Relationships in Cardiac Myocyte Cells and Tissues -- The Intercalated Disc: A Focal Point for Sarcomere Growth and Disease -- Dynamics of Actin in the Heart: Defining Thin Filament Length -- Ca2+ Regulation of the Cardiac Thin Filament -- Posttranslational Modification of the Titin Springs: Dynamic Adaptation of Passive Sarcomere Stiffness -- The M-Band: Not Just Inert Glue but Playing an Active Role in the Middle of the Sarcomere -- Sarcomeric Signaling -- The Nuclear Envelope in Cardiac Health and Disease -- AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart -- How Cardiac Cytoarchitecture Can Go Wrong: Hypertrophic Cardiomyopathy as a Paradigm for Genetic Disease of the Heart -- Cardiac Cytoarchitecture: How to Maintain a Working Heart-Waste Disposal and Recycling in Cardiomyocytes. This book presents a collection of expert reviews on different subcellular compartments of the cardiomyocyte, addressing fundamental questions such as how these compartments are assembled during development, how they are changed in and by disease, and which signaling pathways have been implicated in these processes so far. As such, it offers the first overview of the cell biology of heart disease of its kind, addressing the needs of cell biology students specializing in vascular and cardiac biology, as well as those of cardiologists and researchers in the field of cell biology.