Record Display for the EPA National Library Catalog


Main Title Factors to Be Considered in a Dosimetry Model for Risk Assessment of Inhaled Particles.
Author Martonen, T. ; Hofmann, W. ;
CORP Author Salzburg Univ. (Austria).;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-68-02-2566; EPA/600/J-86/469;
Stock Number PB88-233952
Additional Subjects Air pollution ; Particulates ; Risk ; Carcinogens ; Models ; Radon ; Dosimetry ; Reprints ; Bronchogenic carcinoma ; Carcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB88-233952 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Clinical findings suggest that bronchogenic tumors have a predilection for certain airway locations in man. Aerosol deposition studies with laryngeal-tracheobronchial casts and models indicate that such sites in situ correspond to 'hot spots' of deposition, and that cells located at carinal ridges may be particularly susceptible to development of bronchial carcinomas. For cigarette smokers, the etiology of lung cancer may be affected by synergistic interactions following exposures to naturally occurring indoor radon progeny. The problem is exacerbated for workers in the uranium mining and milling industry due to additional exposures to radioactive dust particles. The paper suggests that heterogeneous local deposition patterns in bronchial airways, concomitant with increased radiation exposure to targeted cells, may be the relevant factor in lung cancer induction, and implies that enhanced activity sites should be accounted for in risk assessment carcinogenesis models.