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RECORD NUMBER: 3 OF 23

Main Title Chloroethane carcinogenicity : (CAS No. 75-00-3).
Author Holder, J. W. ; Jinot, J.
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher U.S. Environmental Protection Agency,
Year Published 1998
Report Number NCEA-W-0018; EPA/600/R-95/099
Stock Number PB98-143274
Subjects Methyl chloride--Toxicology ; Carcinogenicity testing ; Chloroethane--Toxicology ; Carcinogencity testing
Additional Subjects Chlorobenzene ; Carcinogenicity tests ; Health effects ; Chlorobenzenes ; Carcinogens ; Health hazards ; Risk assessment ; Dose-respnse relationships ; Inhalation ; Rats ; Mice ; Malignant neoplasms ; Carcinoma ; Keratoachanthoma ; CAS 75-00-3 ; SAR(Structure-Activity Relationship)
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=9100UUH4.PDF
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB98-143274 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 34 pages : illustrations ; 28 cm
Abstract
Chloroethane (CE; CAS No. 75-00-3) is mutagenic in four tester strains of Salmonella typhimurium, plus and minus S9 activating fraction. Male rats responded with basal cell carcinomas, keratoacanthomas, squamous cell carcinomas, and trichoepitheliomas. Female rats showed brain astrocytomas at an incidence of 3/50 (6%) vs 0/50 (0%) controls vs 1/297 (0.3%) in historical controls. Female mice responded with malignant and metastasizing endo- and myo-metrial cancers. They spread to the lung, ovary, lymph nodes, kidney, adrenal gland, pancreas, mesentery, urinary bladder, spleen, and heart. The SAR, positive mutagenicity, and an exceptional degree and severity of carcinogenicity all indicate that CE causes cancer in rodents and is probably carcinogenic to similarly exposed humans.
Notes
"EPA 600/R-95/099." Includes bibliographical references. "National Center for Environmental Assessment." "April 1998." Microfiche.