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Main Title Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds.
Author Hsie, A. W. ; San Sebastian, J. R. ; Perdue, S. W. ; Schenley, R. L. ; Winters, M. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health. ;Oak Ridge National Lab., TN. ;Pharmakon Research International, Inc., Waverly, PA.
Year Published 1987
Report Number EPA/600/J-87/295;
Stock Number PB88-185137
Additional Subjects Mutagens ; Ovary ; Hamsters ; Chromosomes ; Carcinogens ; Malignant neoplasms ; Reprints ; Cytotoxins ; Hypoxanthine phosphoribosyltransferase ; Sister chromatid exchange ; Carcinoma
Library Call Number Additional Info Location Last
NTIS  PB88-185137 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 21p
Using Chinese hamster ovary (CHO) cells in culture, the authors have defined an assay, CHO/HGPRT, to quantify mutagen-induced cytotoxicity and mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus. This assay permits elucidation of the structure-activity relationship and analysis of relative mutagenic potency of various classes of chemical mutagens. By expanding the CHO/HGPRT assay to include chromosome aberration and sister-chromatid exchange (SCE), the authors can analyze the interrelationships of these four distinct biological effects and compare each endpoint for its predictive power of human-level effect. (Copyright (c) 1987 by Hemisphere Publishing Corporation.)