Record Display for the EPA National Library Catalog
RECORD NUMBER: 36 OF 103| Main Title | Evaluation of the potential carcinogenicity of cyclophosphamide (50-18-01) / | |||||||||||
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| CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA/600/8-91/097; EPA-68-03-3112; EPA-68-03-3182 | |||||||||||
| Stock Number | PB93-185189 | |||||||||||
| Subjects | Aromatic compounds--Carcinogenicity ; Cyclophosphamide--Carcinogenicity | |||||||||||
| Additional Subjects | Carcinogens ; Toxicity ; Cyclophosphamide ; Risk assessment ; Humans ; Animals ; Dose-response relationships ; Carcinogenicity tests ; CAS 50-18-0 | |||||||||||
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| Collation | 24 pages ; 28 cm | |||||||||||
| Abstract | Cyclophosphamide is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Limited. The potency factor (F) for cyclophosphamide is estimated to be 17.5/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, cyclophosphamide is assigned a MEDIUM hazard ranking for the purposes of RQ adjustment. |
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| Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |