Record Display for the EPA National Library Catalog
RECORD NUMBER: 93 OF 335| Main Title | Evaluation of the potential carcinogenicity of acrylonitrile (107-13-1) / | |||||||||||
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| CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA/600/8-91/058; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-002 | |||||||||||
| Stock Number | PB93-181634 | |||||||||||
| Subjects | Aromatic compounds--Carcinogenicity ; Acrylonitrile--Carcinogenicity | |||||||||||
| Additional Subjects | Carcinogens ; Toxicity ; Acrylonitriles ; Carcinogenicity tests ; Humans ; Animals ; Dose-response relationships ; CAS 107-13-1 | |||||||||||
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| Collation | 29 pages ; 28 cm | |||||||||||
| Abstract | Acrylonitrile is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'sufficient' and the evidence from human studies is 'Limited.' The potency factor (F) for acrylonitrile is estimated to be 2.28 (derived from human epidemiology data)/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, acrylonitrile is assigned a 'MEDIUM' hazard ranking for the purposes of RQ adjustment. |
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| Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |