Record Display for the EPA National Library Catalog

RECORD NUMBER: 53 OF 335

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Main Title

Drinking Water Criteria Document for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

CORP Author

Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.

Publisher

Apr 88

Year Published

1988

Report Number

ECAO-CIN-405;

Stock Number

PB90-215294

Additional Subjects

Potable water ; Toxicology ; Water quality ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Liver ; Metabolism ; Vitamin A group ; Tetrachlorodibenzodioxin ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Structure-activity relationship ; Lipid peroxidation

Internet Access

Description	Access URL
	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100T04T.PDF

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB90-215294	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

363p

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is one of the most toxic and environmentally stable tricyclic aromatic compounds belonging to chlorinated dibenzo-p-dioxins. 2,3,7,8-TCDD has been demonstrated to be teratogenic in rats, mice and rabbits, and feticidal in monkeys. The major toxic signs and terata observed were cleft palate in mice, edema, hemorrhage, and kidney anomalies in rats and extra ribs in rabbits. Some epidemiological studies have indicated a possible teratogenic effect in humans, but the evidence is not sufficient to reach a firm conclusion.

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