Record Display for the EPA National Library Catalog
RECORD NUMBER: 25 OF 30
| OLS Field Name | OLS Field Data | |||||||||||
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| Main Title | Neurobehavioral Effects of Carbon Monoxide (CO) Exposure in Humans: Elevated Carboxyhemoglobin (COHb) and Cerebrovascular Responses. | |||||||||||
| Author | Benignus, V. A. ; Petrovick, M. L. ; Prah, J. D. ; | |||||||||||
| CORP Author | Environmental Protection Agency, Research Triangle Park, NC. | |||||||||||
| Publisher | 19 May 89 | |||||||||||
| Year Published | 1989 | |||||||||||
| Report Number | 3E162777A878; CA; | |||||||||||
| Stock Number | AD-A222 840/1 | |||||||||||
| Additional Subjects | Blood ; Blood circulation ; Brain ; Carbon monoxide ; Carboxylic acids ; Cerebrovascular system ; Commercial equipment ; Hemoglobin ; Humans ; Measurement ; Models ; Oxygen ; Reduction ; Response ; Toxicity ; Carboxyhemoglobin | |||||||||||
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| Collation | 58p | |||||||||||
| Abstract | A two-channel cranial impedance plethysmograph (CIP) was designed and constructed as a noninvasive measure of brain blood flow (BBF) in man. The instrument was designed to reduce some of the problems with instability and difficulty of use found in earlier commercially-available models. The CIP has been previously validated against other measures of BBF. During carboxyhemoglobin (COHb) formation, BBF is known to increase. When BBF increases it compensates for the reduced ability of the blood to carry oxygen in the presence of COHb. Fifteen men breathed carbon monoxide (CO) to produce increases in COHb values ranging from endogenous 18.4%. Keywords: Carbon monoxide, CO, Carboxyhemoglobin (COHb), Toxicity, Brain blood flow, Cerebrovascular. (JES) |