| Main Title |
Low-level carbon monoxide exposure and work capacity at 1600 meters / |
| Author |
Weiser, Philip C.
|
| Other Authors |
|
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory ; For sale by the National Technical Information Service, |
| Year Published |
1979 |
| Report Number |
EPA 600/1-79/037; EPA-68-02-2244 |
| Stock Number |
PB80-129083 |
| OCLC Number |
37860229 |
| Subjects |
Carbon monoxide--Physiological effect ;
Work--Physiological aspects ;
Respiration
|
| Additional Subjects |
Carbon monoxide ;
Exercise(Physiology) ;
Air pollution ;
Exposure ;
Physiological effects ;
Concentration(Composition) ;
Performance(Human) ;
Air pollution effects(Humans) ;
Carboxyhemoglobin ;
Environmental health
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-79-037 |
|
Headquarters Library/Washington,DC |
04/25/2014 |
| EKBD |
EPA-600/1-79-037 |
|
Research Triangle Park Library/RTP, NC |
09/07/2001 |
| ELBD ARCHIVE |
EPA 600-1-79-037 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB80-129083 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
viii, 27 p. : tables ; 28 cm. |
| Abstract |
At sea level, low-level carbon monoxide (CO) exposure impairs exercise performance. To determine if altitude residence at 1600 m augments this CO effect, two studies of graded treadmill work capacity were done. The Initial Study investigated nine, non-smoking male subjects breathing either filtered air (FA) or 28 ppm CO in filtered air. End-exercise carboxyhemoglobin (HbCO) levels averaged 0.9 %HbCO breathing FA and 4.7 %HbCO breathing CO. Total work performance and aerobic work capacity were reduced. Work heart rate was elevated, and post-exercise left ventricular ejection time breathing CO did not shorten to the same degree as with FA exposure. CO exposure resulted in a lower anaerobic threshold, and a greater minute ventilation occurred at work rates heavier than the anaerobic threshold due to an increased blood lactate level. The Dose-Response Study exposed twelve subjects to FA or CO such that the end-exercise HbCO levels were 0.7, 3.5, 5.4 and 8.7 %HbCO. Exercise performance and aerobic work capacity were impaired in proportion to the CO exposure. In both studies, maximal cardio-pulmonary responses were not different, but submaximal exercise changes were elevated breathing CO. Thus, in healthy young men residing near 1600 m, an increase in low-level CO exposure produced a linear decrement in maximal aerobic performance similar to that reported at sea level. |
| Notes |
Contract No. EPA 68-02-2244. "EPA-600/1-79-037." Project officer: Edward Haak. Includes bibliographical references (p. 25-26). |
