Record Display for the EPA National Library Catalog


Main Title Absence of Symptoms with Carboxyhemoglobin Levels of 16-23%.
Author Benignus, V. A. ; Kafer, E. R. ; Muller, K. E. ; Case, M. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/298;
Stock Number PB88-185103
Additional Subjects Air pollution ; Carbon monoxide ; Signs and symptoms ; Exposure ; Toxicology ; Blood chemical analysis ; Toxic diseases ; Carbon monoxide poisoning ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB88-185103 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
It has been generally accepted that carboxyhemoglobin levels between 10-20% produce mild headaches, dizziness and/or nausea. Experimental double blind exposures of 18 healthy, nonsmoking young men at rest to 7,000 - 24,000 ppm, designed to elevate COHb to 15-20% in 3-5 minutes, were followed by exposure to 232 ppm CO designed to maintain COHb level for a total of 130 minutes. Resulting COHb values were 16-23%. These COHb values did not produce significantly more symptoms than reported in the control group (n=23). The symptoms which were previously reported in clinical studies of CO poisoning may have resulted from CO exposure in combination with (a) exposure to other substances, (b) stress due to the event that precipitated medical attention or (c) higher COHb levels before the first blood sample was taken. (Copyright (c) Pergamon Journals Ltd. 1987.)